And Gluco Extend glucose support except you will have a physician-diagnosed deficiency in any of those nutrients that you simply can’t fill with food alone, there’s no actual need to supplement at all. “At best, super-excessive doses of nutrients are shopping for you costly urine, and at worst, they may contribute to the event of chronic diseases,” she says. While research show supplementing with excessive doses does assist construct muscle mass and enhance energy over time, it’s not pre-workout in the strict sense, in that timing doesn’t really matter. Taking smaller doses more incessantly through the day might also be an possibility, however it is best to discuss any modifications in your medication timing or dosage together with your physician before experimenting on your own. For example, a 2017 study in the Journal of Clinical Oncology discovered that long-time period supplementation with high doses of vitamin B6 and B12 might considerably enhance the chance of lung cancer in men